Dr. Aleksandar Obradovic received his MD and PhD degrees from Columbia University in 2023, graduating in the Department of Systems Biology under the joint mentorship of Dr. Andrea Califano and Dr. Charles Drake. Dr. Obradovic is currently an Associate Research Scientist in the Columbia Department of Medicine in the Division of Experimental Therapeutics, and a resident physician in Internal Medicine at New York Presbyterian Hospital. His research focus is on the development of novel approaches for analysis of transcriptional, TCR-Seq, and spatial data, at the bulk and single-cell level, applying these tools across clinical data toward an improved understanding of the immunologic mechanisms of resistance to checkpoint inhibitors and the discovery of synergistic combination therapies.